Press Release


					
Biocytogen Enters into Antibody Agreement with Ona Therapeutics to Develop Antibody-Drug Conjugates Targeting Solid Tumors

					

					


					

						

							

								
Beijing, China and Barcelona, Spain, December 18th, 2023 – Biocytogen Pharmaceuticals (Beijing) Co., Ltd. (“Biocytogen”, HKEX: 02315), a global biotech company focusing on the discovery and development of novel antibody therapeutics, today announces an antibody evaluation, option and license agreement with Ona Therapeutics (“Ona”), a Spanish biotech company specialized in unravelling novel biology to design biopharmaceuticals attacking advanced cancer.


Under the terms of the agreement, Biocytogen will grant Ona access to evaluate Biocytogen’s proprietary RenMice®-derived fully human antibodies against a specific tumor target, with an option to exclusively license selected antibodies for antibody-drug conjugate (ADC) development, manufacturing and commercialization in mutually agreed indications and territories.


Biocytogen will receive an upfront payment for granting the option, and will be further entitled to an option-exercise fee, development and commercialization milestone payments, as well as single-digit royalties on net sales once Ona elects to exercise the option in full.


Dr. Yuelei Shen, President and CEO of Biocytogen, said: “As part of Project Integrum, Biocytogen has been discovering fully human antibodies against 200 TAA targets based on their internalization activity. We are honored that Ona, among other global biopharmaceutical companies, recognizes the potential of our proprietary off-the-shelf antibodies. We believe Ona’s deep understanding of novel mechanisms of resistance in advanced cancer and their capabilities in ADC design and development will accelerate the development of our antibodies into promising therapeutics.”


Dr. Valerie Vanhooren, CEO & co-founder of Ona, said: “We look forward to evaluating Biocytogen’s proprietary antibodies for ADC uses. We believe the combination of Biocytogen’s rich antibody repertoire with Ona’s unique insight in advanced cancer biology will have great advantages in the discovering and developing of first-in-class molecules for unmet medical needs.”


About Biocytogen

Biocytogen (HKEX: 02315) is a global biotechnology company that drives the research and development of novel antibody-based drugs with innovative technologies. Founded on gene editing technology, Biocytogen leverages genetically engineered proprietary RenMice® (RenMabTM/RenLite®/RenNano®/RenTCR-mimicTM) platforms for fully human monoclonal/bispecific/multispecific antibody discovery, bispecific antibody-drug conjugate discovery, nanobody discovery and TCR-mimic antibody discovery, and has established an off-the-shelf library of >400,000 fully human antibody sequences against approximately 1000 targets for worldwide collaboration. As of June 30, 2023, 50 therapeutic antibody and multiple clinical asset co-development/out-licensing/transfer agreements and 42 target-nominated RenMice® licensing projects have been established around the globe, including several partnerships with multinational pharmaceutical companies (MNCs).


Biocytogen pioneered the generation of drug target knock-in humanized models for preclinical research, and currently provides a few thousand off-the-shelf animal and cell models under the company’s sub-brand, BioMiceTM, along with preclinical pharmacology and gene-editing services for clients worldwide. Headquartered in Beijing, Biocytogen has branches in China (Haimen Jiangsu, Shanghai), USA (Boston, San Francisco), and Germany (Heidelberg). For more information, please visit http://en.biocytogen.com.cn.


About Ona Therapeutics

Ona, headquartered in the Barcelona Science Park (PCB), Barcelona, Spain, is a biotech company that specializes in unravelling novel biology to design first-in-class biopharmaceuticals attacking advanced cancer. The company was founded in 2019 as a spin-off from ICREA and the IRB Institute for Research in Biomedicine. In 2020, Ona raised a EUR 30 million Series A investment round from an international syndicate of life sciences specialist investors. Ona was named by Fierce Biotech as one of 2020’s Fierce 15 biotechnology companies. For more information please visit: www.ona-therapeutics.com.


							

						

					

				

			

		

	

			

					


					
			
  
  
  
  














    
  
  
  
    

          
        
            

        


  Ona Therapeutics


        
    
          

  • 
  

    • 

  
  • 
    
  
    • 


  
  • 
    
  
    • 


  
  • 
    
  
    • 
        

        


  		Powered by ONA THERAPEUTICS, SL  GDPR Cookie Compliance
		

      

      
      

        

           
        

        
        


          

            


      Privacy Overview
    

  	
ONA THERAPEUTICS, SL obtains personal data through the contact forms of the web, from those who submit any questions, requests and / or comments.


In accordance with current regulations on Data Protection, specifically, Regulation (EU) 2016/679 of the European Parliament and of the Council, of April 27, 2016, personal data provided to ONA THERAPEUTICS, SL through this web portal will become part of its information systems that comply with the security measures required in order to guarantee the confidentiality, integrity, security and information retrieval.


The purposes for which these data are collected are those of being able to respond to your queries regarding the services we offer. In addition, of the timely response to your queries, we may, if you authorize us to do so, send you information electronically.


Your data will be kept for the period that you are registered to receive the requested information, being your revocable consent, it may be withdrawn at any time through the link that accompanies each shipment to communicate your WITHDRAWN or through an email to the address info@ona-therapeutics.com. From that moment, you will no longer receive any communication from us.


We will not proceed with the communication or transfer of your data, in any case, unless a public body requires it in accordance with the Law and those in charge of treatment that provide services related to our information systems.


You have the right to obtain confirmation about whether we are treating your personal data, therefore, you have the right to access your personal data (Right of Access), you have the right to rectify inaccurate data (Right of Rectification) or to request its deletion (Right to deletion) when the data is no longer necessary, you have the right to exercise your opposition to the processing of data (Right of opposition), to exercise your right to the limitation of the processing, as well as you will have the right to the portability of your data, if it is the case. All this by writing to our access addresses in Calle Baldiri Reixach 10, Barcelona, ​​Spain or via email info@ona-therapeutics.com in accordance with the procedure of articles 15 to 23 of Regulation (EU) 2016 / 679 of the European Parliament and of the Council, of April 27, 2016.


ONA THERAPEUTICS, SL, declares to have implemented the necessary technical and organizational security measures that guarantee the security of the data and prevent its alteration, loss, treatment or unauthorized access, taking into account the state of the technology, the nature of the stored data and the risks to which they are exposed, already come from human action or from the physical or natural environment.


To protect the privacy of the USERS, it is prohibited to send any information regarding their ideology, religion, beliefs, racial origin, health, and sexual life through our forms.


Likewise, we inform you that, under no circumstances will automated individual decisions or profiling be made.